The association with cardiovascular disease was also present in a separate population representative sample in NHANES 2005/06 (n = 1493), despite a decrease in uBPA concentrations of around 30% compared to the 2003/04 results.
#Magicad 2010.11 full
Higher BPA concentrations were associated with cardiovascular diagnoses (OR per one SD increase in BPA concentration 1.39, 95% CI 1.18–1.63 p = 0.001 with full adjustment). The first major epidemiological analyses of adult health effects associated with exposure to BPA involved a study of 1455 adults aged 18 to 74 years with measured urinary BPA (uBPA) from the US National Health and Nutrition Survey (NHANES) 2003–2004. The main source of exposure for humans is not clearly understood, but is most likely through consumption of packaged food and beverages, with additional exposure from drinking water, dental sealants, dermal exposure and inhalation of household dusts. Ubiquitous human exposure to BPA is evident from the presence of detectable concentrations of BPA metabolites in the urine of 80–90% of the population worldwide. BPA is classified as an endocrine disrupting chemical (EDC) due to reported interference in hormonal function and signaling, especially in relation to estrogen receptor-mediated pathways. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.īisphenol A (BPA) is a synthetic monomer used in the manufacture of polycarbonate plastics and in the epoxy resins lining food and beverage containers, and is one of the world’s highest production volume chemicals. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: David Melzer and Tamara Galloway’s work on BPA has been supported by unrestricted funds from the University of Exeter ( the Peninsula Clinical Research facility ( and by grant funding from the British Heart Foundation ( - grant reference PG/09/097). Received: MaAccepted: JPublished: August 15, 2012Ĭopyright: © Melzer et al. PLoS ONE 7(8):Ĭalifornia Pacific Medicial Center Research Institute, United States of America (2012) Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis. There was no significant uBPA difference between patients with severe CAD (needing surgery) and the remaining groups combined.Ĭitation: Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, et al. Compared to those with normal coronary arteries, uBPA concentration was significantly higher in those with severe CAD (OR per uBPA SD = 5.96 ng/ml OR = 1.43, CI 1.03 to 1.98, p = 0.033), and near significant for intermediate disease (OR = 1.69, CI 0.98 to 2.94, p = 0.061). The (unadjusted) median uBPA concentration was 1.28 ng/mL with normal coronary arteries, and 1.53 ng/mL with severe CAD. Severe (one to three vessel) CAD was present in 385 patients, 86 had intermediate disease (n = 86) and 120 had normal coronary arteries. Linear models were adjusted for BMI, occupational social class and diabetes status. 591 patients participating in The Metabonomics and Genomics in Coronary Artery Disease (MaGiCAD) study in Cambridgeshire UK, comparing urinary BPA (uBPA) with grades of severity of coronary artery disease (CAD) on angiography. To estimate associations between BPA exposure and angiographically graded coronary atherosclerosis.
0 kommentar(er)
